生物
T细胞
免疫系统
CD8型
细胞生物学
免疫学
Cd4 t细胞
细胞毒性T细胞
白细胞介素21
遗传学
体外
作者
D.S.M. Chatzileontiadou,Hannah Sloane,Andrea Nguyen,Stéphanie Gras,Emma J. Grant
摘要
As a major arm of the cellular immune response, CD4+ T cells are important in the control and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral role in the development and activation of B cells and CD8+ T cells. CD4+ T cells are incredibly heterogeneous, and can be divided into six main lineages based on distinct profiles, namely T helper 1, 2, 17 and 22 (Th1, Th2, Th17, Th22), regulatory T cells (Treg) and T follicular helper cells (Tfh). Recent advances in structural biology have allowed for a detailed characterisation of the molecular mechanisms that drive CD4+ T cell recognition. In this review, we discuss the defining features of the main human CD4+ T cell lineages and their role in immunity, as well as their structural characteristics underlying their detection of pathogens.
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