纳米技术
体内
材料科学
癌症治疗
免疫系统
硒
癌症研究
介孔二氧化硅
癌症
药理学
医学
介孔材料
化学
免疫学
生物
生物化学
内科学
催化作用
生物技术
冶金
作者
Qian Chen,Tianzhi Liu,Shixiong Chen,Yu Luo,Ming Ma,Fengfeng Xue,Linlin Zhang,Weichao Bao,Hangrong Chen
标识
DOI:10.1021/acsami.9b15774
摘要
Developing versatile nanomaterials has offered a myriad of opportunities to surmount cancer. In particular, the combination of therapy and immunomodulatory effect to further enhance immune response provides a new idea for effective tumor treatment. Herein, for the first time, an in situ growth strategy is developed to construct highly dispersed noncrystalline selenium nanoparticles (Se NPs) with thiolated cyclo(Arg-Gly-Asp-Phe-Lys-(mpa)) (RGD) peptide modification (R-Se@DMSND) for targeted cancer treatment. Se NPs could be homogeneously grown into the pore channels of dendritic mesoporous silica nanoparticles (DMSNs) since the DMSNs could stabilize Se NPs to prevent their aggregations. Moreover, Se NPs could not only act as a therapeutic agent, inducing ROS overproduction, to effectively suppress primary tumor but also as an immunomodulatory agent to simultaneously inhibit the growth of secondary tumors by enhancement of the immune response, as confirmed by the in vivo results. Such the therapeutic-immunomodulatory strategy for tumorous therapy combining with immunomodulation using one simple nanoplatform may pave a new avenue in the biomedical field.
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