Effeet of different doses of neostigmine on recovery from cisatracurium induced neuromuscular blockade

Objective To investigate the effect of different doses of neostigmine administration on recovery from cisatracrium induced neuromuscular blockade. Methods Thirty-six patients(ASA Ⅰ and Ⅱ) were divided into three groups(each twelve),and received neostigmine 20,35 and 50 μg/kg respectively. Results The speed of recovery from cisatracurium-induced neuromuscular blockade with neostigmine 20 μg/kg was lower as compared with 35 μg/kg and 50 μg/kg,but the difference was not significant between with neostigmine 35 μg/kg and 50 μg/kg. Conclusions Recovery from cisatracurium-induced neuromuscular blockade was accelerated when dose of neostigmine was increased from 20 μg/kg to 50 μg/kg,35 μg/kg is the optimal dose of neostigmine for reversal of cisatracufium-induced neuromuscular blockade. Key words: Neostigmine; Cisatracurium; Muscle relaxation; Antagonists