医学
卵巢癌
上皮性卵巢癌
内科学
癌症
肿瘤科
卵巢肿瘤
癌症研究
白细胞介素6
免疫组织化学
转移
受体
免疫系统
临床意义
阶段(地层学)
出处
期刊:Central Plains Medical Journal
日期:2019-10-10
卷期号:46 (19): 27-31
标识
DOI:10.3760/cma.j.issn.1674-4756.2019.19.008
摘要
Objective
To study the expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) in ovarian cancer tissues and its relationship with prognosis of ovarian cancer patients.
Methods
The tumor tissue samples of 94 patients admitted to People’s Hospital of Shouguang Affiliated to Weifang Medical College from 2006 to 2011 were selected as the research objects. The expression levels of IL-6 and IL-6R in tumor tissues were detected by immunohistochemistry. The survival data of patients were analyzed by Kaplan-Meier method. The Cox proportional hazard regression model was used for multivariate analysis.
Results
Of the 94 patients, 39 cases (41.5%) showed high expression of IL-6, and 32 cases (34.0%) showed high expression of IL-6R. There was no significant difference in progression-free survival and overall survival between patients with low expression of IL-6 and patients with high expression of IL-6 (P>0.05). The progression-free survival of patients with high expression of IL-6R was significantly lower than that of patients with low expression of IL-6R (P 1 cm (HR: 2.262; 95% CI: 1.301- 5.513; P=0.007), and FIGO stage Ⅲ/Ⅳ (HR: 12.92; 95% CI: 4.080-57.172; P<0.001) were independent risk factors of progression-free survival in patients with ovarian cancer.
Conclusions
IL-6R is an independent risk factor for progression-free survival of ovarian cancer patients and can be used for prognosis prediction in ovarian cancer patients.
Key words:
Ovarian cancer; Interleukin-6; Interleukin-6 receptor; Immunohistochemistry; Prognosis
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