异甘草素
神经保护
超氧化物歧化酶
谷胱甘肽过氧化物酶
过氧化氢酶
抗氧化剂
活性氧
乳酸脱氢酶
化学
氧化应激
药理学
传统医学
医学
生物
生物化学
酶
作者
Dingding Shi,Jiali Yang,Yueming Jiang,Li Wen,Zhubin Wang,Bao Yang
标识
DOI:10.1016/j.freeradbiomed.2020.03.016
摘要
Glycyrrhizae radix has been widely accepted as a functional food in Asia. Isoliquiritigenin is a characteristic bioactive chemical in this medicinal plant. In this work, the neuroprotective effect of isoliquiritigenin and the possible mechanisms were investigated. The results revealed that isoliquiritigenin exhibited better neuroprotective and antioxidant activities than quercetin, a commercial natural antioxidant. Isoliquiritigenin significantly inhibited the release of lactate dehydrogenase, and the generation of reactive oxygen species in H2O2-treated cells. The activities of superoxide dismutase, glutathione peroxidase and catalase were improved. The mRNA expression levels related to oxidative defense and cell apoptosis were reversed by isoliquiritigenin. Moreover, isoliquiritigenin might inhibit the cell apoptosis via ameliorating the loss of mitochondrial membrane potential and the change of nucleus morphology.
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