Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome

Abstract Staphylococcal scalded skin syndrome causes widespread skin denudation primarily in infants < 1 year old. Selection of empiric therapy is complicated by rising rates of antibiotic resistance in community‐acquired staphylococcal infections. Consistent with a previous study, this retrospective review found that SSSS‐associated isolates were more likely to be clindamycin‐resistant and less likely to be methicillin‐resistant compared to overall staphylococcal infections. We favor cephalosporins and penicillinase‐resistant penicillins (eg, oxacillin) for empiric management of SSSS, with consideration of adding MRSA coverage in communities with high MRSA prevalence or failure to improve following several days of treatment.