杯状细胞
粘蛋白
粘液
囊性纤维化
粘液纤毛清除率
化生
呼吸上皮
生物
免疫学
病理生理学
呼吸道疾病
呼吸系统
上皮
病理
肺
医学
内科学
解剖
生态学
遗传学
作者
Olivier Boucherat,Jorge Boczkowski,Lucie Jeannotte,Christophe Delacourt
标识
DOI:10.3109/01902148.2013.791733
摘要
The mucociliary system, consisting of mucus-secreting goblet cells and ciliated cells, generates a constant overturning layer of protective mucus that lines the airway epithelium. Mucus hypersecretion and the pathophysiological changes associated are hallmarks of many pulmonary diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Excessive mucus production leads to airway obstruction and, because there is currently no effective treatment, contributes to morbidity and mortality of many patients. Goblet cell differentiation and mucus production are subject to extensive control. An emerging concept is that not all goblet cells are phenotypically identical suggesting that specific molecular pathways orchestrate mucin overproduction. This paper attempts to describe the cellular and molecular mechanisms governing the differentiation of goblet cells in pulmonary diseases, a prerequisite for the development of new therapeutic agents.
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