苄丝肼
左旋多巴
卡比多巴
帕金森病
医学
脱羧酶抑制剂
不利影响
交叉研究
药理学
临床试验
麻醉
内科学
帕金森病
安慰剂
疾病
替代医学
病理
作者
J.K. Greenacre,Angela Coxon,Aviva Petrie,John L. Reid
出处
期刊:The Lancet
[Elsevier]
日期:1976-08-01
卷期号:308 (7982): 381-384
被引量:28
标识
DOI:10.1016/s0140-6736(76)92403-x
摘要
The therapeutic efficacy and side-effects of two preparations of levodopa with extracerebral decarboxylase inhibitors have been compared in 19 patients with idiopathic parkinsonism in a blind randomised crossover trial. The mean daily dose of levodopa was 658±64 mg/day (mean±S.E.M.) when given together with carbidopa 66 mg/day and 605±59 mg/day when levodopa was combined with benserazide 151 mg/day. There was no significant difference between the treatment regimens either in beneficial effects on parkinsonian symptoms and signs or in the adverse effects of levodopa assessed by a clinical observer unaware of the treatment given. Of the 19 patients studied, 9 preferred the carbidopa preparation, 8 preferred the benserazide preparation, and 2 had no preference. It is concluded that there is no significant difference in therapeutic effects or adverse reactions between the two commercially available decarboxylase-inhibitor-containing preparations. Central-nervous-system actions and side-effects depend on the daily dose of levodopa, regardless of the different ratios of decarboxylase inhibitors to levodopa.
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