受体
肾上腺素能受体
血压
咪唑啉受体
突变体
肾上腺素能的
内科学
内分泌学
生物
基因
药理学
脑干
医学
遗传学
作者
Leigh B. MacMillan,Lutz Hein,Marta S. Smith,Michael T. Piascik,Lee E. Limbird
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-08-09
卷期号:273 (5276): 801-803
被引量:455
标识
DOI:10.1126/science.273.5276.801
摘要
alpha2-Adrenergic receptors (alpha2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three alpha2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of alpha2AR agonists with imidazoline receptors has precluded an understanding of the role of individual alpha2AR subtypes in the hypotensive response. Gene targeting was used to introduce a point mutation into the alpha2aAR subtype in the mouse genome. The hypotensive response to alpha2AR agonists was lost in the mutant mice, demonstrating that the alpha2aAR subtype plays a principal role in this response.
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