化学
电位滴定法
质谱法
质子化
胱氨酸
羧酸盐
氧化还原
化学计量学
解吸
金属
无机化学
配体(生物化学)
电化学
分析化学(期刊)
色谱法
立体化学
物理化学
离子
有机化学
电极
吸附
生物化学
半胱氨酸
受体
酶
作者
Emilia Furia,Donatella Aiello,Leonardo Di Donna,Fabio Mazzotti,Antonio Tagarelli,Hariprasad Thangavel,Giovanni Sindona
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2014-01-01
卷期号:43 (3): 1055-1062
被引量:31
摘要
Cd(II)–, Pb(II)– and Zn(II)–cystine complexes were investigated by potentiometric and different mass spectrometric (MS) methodologies. Laser desorption mass spectrometry has provided both the composition and structure of metal–cystine complexes according to the speciation models proposed on the basis of the potentiometric data. Detection of neutral complexes was achieved by protonation or electrochemical reduction during mass spectrometric experiments. The redox activity of metal–cystine complexes was confirmed by laser desorption and charge transfer matrix assisted laser assisted MS experiments, which allowed us to observe the formation of complexes with a reduction of cystine. The stoichiometry of Cd(II)–, Pb(II)– and Zn(II)–cystine complexes was defined by observing the isotopic pattern of the investigated compound. The results suggest that interaction occurs through the carboxylate group of the ligand.
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