Experiment on Hemostasis for Wounds with Collagen Sponge

Objective The different types of collagen sponge and their effect on bleeding wounds were studied. Methods The soluble collagen was extracted from bovine tendon and lyophilized to become a spongy hemostatic material. The constituents of collagen sponge were analyzed by SDS-PAGE electrophoresis. The hemostatic effect of different types of collagen sponge was studied on the sterile and infected wounds in rabbit.Results It was demonstrated that the collagen sponge composed of type Ⅰ collagen possessed of the effectiveness in shortening hemostatic duration, reducing bleeding and improving wound cure. Conclusion Collagen sponge is a good hemostatic material. It can be used as tampon for treatment of wounds.