生物信息学
广告
IVIVC公司
计算机科学
计算生物学
生化工程
碳酸钙-2
化学
生物制药分类系统
生物信息学
细胞
生物利用度
体外
生物
生物化学
溶解试验
工程类
基因
作者
Huong Le-Thi-Thu,Miguel Ángel Cabrera-Pérez,Nguyen Hai Nam,Juan A. Castillo-Garit,Bakhtiyor Rasulev,Huong Le-Thi-Thu,Gerardo M. Casañola-Martin
标识
DOI:10.2174/1568026619666181130140350
摘要
One of the main goals of in silico Caco-2 cell permeability models is to identify those drug substances with high intestinal absorption in human (HIA). For more than a decade, several in silico Caco-2 models have been made, applying a wide range of modeling techniques; nevertheless, their capacity for intestinal absorption extrapolation is still doubtful. There are three main problems related to the modest capacity of obtained models, including the existence of inter- and/or intra-laboratory variability of recollected data, the influence of the metabolism mechanism, and the inconsistent in vitro-in vivo correlation (IVIVC) of Caco-2 cell permeability. This review paper intends to sum up the recent advances and limitations of current modeling approaches, and revealed some possible solutions to improve the applicability of in silico Caco-2 permeability models for absorption property profiling, taking into account the above-mentioned issues.
科研通智能强力驱动
Strongly Powered by AbleSci AI