生物制药
药剂学
溶解度
生物利用度
结晶习性
结晶
晶体工程
材料科学
药学
药品
化学
纳米技术
化学工程
有机化学
分子
药理学
医学
生物技术
工程类
氢键
生物
作者
Jaleh Varshosaz,Erfaneh Ghassami,Saeedeh Ahmadipour
标识
DOI:10.2174/1381612824666180712104447
摘要
Background: Crystal engineering is dealing with the creation of new structures and new properties in drug molecules through inter-molecular interactions. Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the problems of more than 40% of the new designed drugs which suffer from low solubility and consequently, low bioavailability which have limited their clinical application. Methods: This review covers a broad spectrum of aspects of the application of crystal engineering in pharmaceutics and includes a comprehensive wide range of different techniques used in crystal engineering of active pharmaceutical ingredients (API) to compensate the low water solubility and bioavailability of drugs related specially to class II of biopharmaceutical classification system (BCS). Results: These techniques include; crystalline habit modification, polymorphism, solvates and hydrates, cocrystals, surface modification, crystallization, spherical agglomeration, liquisolid crystals and solid dispersions which are introduced and discussed in this review article. Conclusion: Each of these techniques has advantages and limitations which are emphasized on them.
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