胰腺癌
蛋白激酶B
PI3K/AKT/mTOR通路
基因敲除
癌症研究
CA19-9号
癌症
连环素
医学
下调和上调
内科学
信号转导
Wnt信号通路
化学
生物
细胞凋亡
细胞生物学
基因
生物化学
作者
Qingya Hao,Lihua Gao,Wenyang Niu,Liang Chen,Peng Zhang,Zhong Chen
出处
期刊:Biofactors
[Wiley]
日期:2020-06-26
卷期号:46 (4): 685-692
被引量:6
摘要
Abstract To explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK‐3β inhibitor, proliferative change in pancreatic cancer cells was assessed. Protein levels of vital genes in the PI3K/Akt/GSK‐3β/β‐catenin signaling influenced by POTEE were examined. POTEE was upregulated in pancreatic cancer samples. High level of POTEE indicated advanced tumor staging, large tumor size, and poor prognosis in pancreatic cancer patients. Knockdown of POTEE or treatment of Tideglusib remarkably attenuated proliferative ability in pancreatic cancer cells. Vital genes in the PI3K/Akt/GSK‐3β/β‐catenin signaling were downregulated by knockdown of POTEE. POTEE stimulates the proliferative ability in pancreatic cancer by activating the PI3K/Akt/GSK‐3β/β‐catenin signaling. High level of POTEE indicates advanced tumor staging, large tumor size and poor prognosis in pancreatic cancer patients.
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