肠沙门氏菌
抗菌剂
鲍曼不动杆菌
微生物学
抗生素耐药性
细菌
抗生素
大肠杆菌
沙门氏菌
多重耐药
生物污染
不动杆菌
革兰氏阴性菌
病菌
化学
铜绿假单胞菌
生物
膜
生物化学
基因
遗传学
作者
Marcelo Der Torossian Torres,Sahag Voskian,Paul Brown,Andong Liu,Timothy K. Lu,T. Alan Hatton,César de la Fuente-Núñez
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-01-13
卷期号:15 (1): 966-978
被引量:25
标识
DOI:10.1021/acsnano.0c07642
摘要
Antibiotic-resistant bacteria infect close to 3 million people, and kill 35,000, each year in the United States. Ionic liquid (IL)-based antimicrobial agents have the potential to diversify our ever-diminishing antibiotic arsenal. Here, we describe an IL with potent submicromolar antimicrobial activity in vitro against clinically relevant Gram-negative and Gram-positive bacterial pathogens as well as anti-infective activity in a mouse model. The IL kills pathogenic bacteria such as Acinetobacter baumannii, Salmonella enterica, and Escherichia coli by disrupting their outer membrane and does not select for bacterial resistance. We show incorporation of our IL into surface coatings to generate a type of antibiofilm material. The IL-loaded ionogel surfaces demonstrate high-antimicrobial and antifouling activity by killing bacteria in both static and dynamic tests. Our IL-based antibiofilm surfaces are low-cost and easy to manufacture, can be formed on glass, latex, plastic, and metal surfaces, such as catheters and other medical devices where high local concentrations of antimicrobials are needed, and may have applications in other clinical and industrial settings.
科研通智能强力驱动
Strongly Powered by AbleSci AI