转移
CXCR4型
肿瘤微环境
趋化因子
趋化因子受体
癌症研究
调解人
肿瘤进展
生物
原发性肿瘤
癌症
受体
肿瘤细胞
细胞生物学
生物化学
遗传学
出处
期刊:Life Sciences
[Elsevier]
日期:2020-05-01
卷期号:249: 117534-117534
被引量:95
标识
DOI:10.1016/j.lfs.2020.117534
摘要
Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple cells within the tumor microenvironment (TME) aiming for tumor progression and metastasis. The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.
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