抗菌剂
抗生素
抗真菌
分离(微生物学)
抗生素耐药性
天然产物
药物发现
药品
生物
化学
计算生物学
组合化学
微生物学
药理学
立体化学
生物信息学
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2020-05-18
卷期号:20 (7): 584-600
被引量:15
标识
DOI:10.2174/1389557519666191205124050
摘要
The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of serious public health problem all over the world. In this sense, natural products have been a rich source of compounds for drug discovery with antibiotic activity. Macrolactins are amazing structures which have antibiotic activity against some clinically relevant pathogens. In addition, they have anti-inflammatory, antifungal, antimicrobial, and antitumor activities. They are macrolides containing 24-membered lactone ring with some differences in their chemical structures. The synthesis of these compounds is a difficult task which has attracted attention of researchers; however few syntheses have been reported. In this review, the isolation of all reported macrolactins, their syntheses and biological activities are revisited.
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