铜绿假单胞菌
四环素
抗生素
微生物学
抗生素耐药性
佐剂
四环素类抗生素
化学
细菌
生物
免疫学
遗传学
作者
Azza Troudi,Hana Douafer,Jean‐Michel Bolla,Naouel Klibi,Jean Michel Brunel
出处
期刊:Anti-infective agents
[Bentham Science]
日期:2021-03-24
卷期号:19 (1): 110-116
被引量:2
标识
DOI:10.2174/2211352518999200629164624
摘要
Introduction: An attractive antibiotic-adjuvant strategy consisting of the design and synthesis of polyaminoisoprenyl molecules able to restore the antibiotic activity of tetracycline antibiotics against resistant Pseudomonas aeruginosa bacterial strains has been developed. Methods: These chemo-sensitizers are readily prepared from geraniol and farnesol in an efficient two steps synthesis with good to moderate yields varying from 38 to 64% and leading to a significant decrease in antibiotic resistance. Results: Thus, the influence of the nature of the tetracycline antibiotic used as well as the structure of the polyaminoisoprenyl derivatives involved in the outcome of the antibiotic-adjuvant combination against P. aeruginosa resistance to tetracyclines were investigated. Conclusion: Additionally, our data suggested that their mechanism of action is closely associated with the increase of the outer-membrane permeability.
科研通智能强力驱动
Strongly Powered by AbleSci AI