绷带
催化作用
氧化应激
活性氧
神经炎症
抗氧化剂
体内
化学
生物物理学
光化学
医学
炎症
生物化学
有机化学
内科学
生物
生物技术
作者
Ruijuan Yan,Si Sun,Jiang Yang,Wei Long,Junying Wang,Xiaoyu Mu,Qifeng Li,Wenting Hao,Shaofang Zhang,Haile Liu,Yalong Gao,Lufei Ouyang,Junchi Chen,Shuangjie Liu,Xiaodong Zhang,Dong Ming
出处
期刊:ACS Nano
[American Chemical Society]
日期:2019-09-25
卷期号:13 (10): 11552-11560
被引量:206
标识
DOI:10.1021/acsnano.9b05075
摘要
Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount of reactive oxygen and nitrogen species (RONS) around the wound, triggering a series of biochemical responses and neuroinflammation. Traditional antioxidant-based bandages can effectively decrease infection via preventing oxidative stress, but its effectiveness is limited to a short period of time due to the rapid loss of electron-donating ability. Herein, we developed a nanozyme-based bandage using single-atom Pt/CeO2 with a persistent catalytic activity for noninvasive treatment of neurotrauma. Single-atom Pt induced the lattice expansion and preferred distribution on (111) facets of CeO2, enormously increasing the endogenous catalytic activity. Pt/CeO2 showed a 2–10 times higher scavenging activity against RONS as well as 3–10 times higher multienzyme activities compared to CeO2 clusters. The single-atom Pt/CeO2 retained the long-lasting catalytic activity for up to a month without obvious decay due to enhanced electron donation through the Mars–van Krevelen reaction. In vivo studies disclosed that the nanozyme-based bandage at the single-atom level can significantly improve the wound healing of neurotrauma and reduce neuroinflammation.
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