An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell deathin vitroand elicits effective anti-tumour immune responsesin vivo

A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.