体内
免疫疗法
巨噬细胞极化
癌症研究
材料科学
肿瘤相关巨噬细胞
M2巨噬细胞
肿瘤微环境
甘露糖受体
巨噬细胞
癌症免疫疗法
免疫系统
体外
化学
医学
免疫学
肿瘤细胞
生物
生物化学
生物技术
作者
Ké Li,Lu Lu,Chencheng Xue,Ju Liu,Ye He,Jun Zhou,Zengzilu Xia,Liangliang Dai,Zhong Luo,Yulan Mao,Kaiyong Cai
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2020-01-01
卷期号:12 (1): 130-144
被引量:84
摘要
Tumor-associated macrophages (TAMs) are the most important components in the tumor immunosuppressive microenvironment, promoting tumor growth and metastasis. Although TAMs have become one of the hot topics of tumor immunotherapy, challenges still remain to achieve TAM-targeted re-polarization therapy. In this work, porous hollow iron oxide nanoparticles (PHNPs) were synthesized for loading a P13K γ small molecule inhibitor (3-methyladenine, 3-MA) and further modified by mannose to target TAMs. The delivery system named PHNPs@DPA-S-S-BSA-MA@3-MA showed good efficiency for targeting TAMs. The inflammatory factor NF-κB p65 of macrophages was activated by the combination of PHNPs and 3-MA, which synergistically switched TAMs to pro-inflammatory M1-type macrophages. As a result, it activated immune responses and inhibited tumor growth in vivo. The study provides an intracellular switch of the TAM phenotype for targeted TAM therapy.
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