剪切(物理)
分散性
制作
纳米技术
微流控
材料科学
化石燃料
微球
化学工程
化学
复合材料
工程类
高分子化学
医学
病理
有机化学
替代医学
作者
Guosheng Tang,Ranhua Xiong,Dan Lv,Ronald X. Xu,Kevin Braeckmans,Chaobo Huang,Stefaan C. De Smedt
标识
DOI:10.1002/advs.201802342
摘要
Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro- and nanoscales remains challenging. Here, a simple one-step and oil-free process, based on the gas-flow-assisted formation of microdroplets ("gas-shearing"), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil-free gas-shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas-shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil-free gas-shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications.
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