化学
外消旋化
试剂
磷酸
肽合成
肽
质谱法
组合化学
有机化学
色谱法
生物化学
作者
Nagnnath D. Kokare,Rahul R. Nagawade,Vipul P. Rane,Devanand B. Shinde
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2007-03-01
卷期号:2007 (5): 766-772
被引量:7
标识
DOI:10.1055/s-2007-965918
摘要
Highly efficient coupling reagents - phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester, diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester and phosphoric acid diphenyl ester 2-phenylbenzimidazol-1-yl ester - were designed, synthesized and successfully applied in peptide coupling reactions. Their efficiency was evaluated through the synthesis of a range of amides and peptides, and the extent of racemization was studied by HPLC and found to be negligible. The mechanism of action is probably similar to those found for organophoshorus esters of hydroxybenzotriazole: a presumption supported by the isolation and characterization by mass spectrometry and 1H NMR of some of the proposed intermediates.
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