化学
烷基化
丁二酰亚胺
催化作用
氯化苄
卤化物
苯并咪唑
吩噻嗪
有机化学
选择性
乙酰胺
相转移催化剂
相(物质)
药物化学
医学
药理学
作者
István Greiner,Fanni D. Sypaseuth,Alajos Grűn,Éva Karsai,György Keglevich
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2009-10-01
卷期号:6 (7): 529-534
被引量:6
标识
DOI:10.2174/157017809789869546
摘要
The effect of triethylbenzylammonium chloride (TEBAC) was studied on the outcome of the microwaveassisted solid-liquid phase N-alkylation of amides, imides and N-heterocycles using benzyl halides and K2CO3. It was found that while the benzylation of amides may be somewhat promoted by the presence of TEBAC, succinimide and benzimidazole are so reactive that there is no need to use the catalyst. At the same time, the outcome of the benzylation of phenothiazine may be significantly influenced by the presence or absence of TEBAC in respect of N- versus C-alkylation. Keywords: N-alkylation, microwave, phase transfer catalysis, selectivity
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