Dual histamine blockade for the treatment of adult functional dyspepsia: a single centre experience

We read with interest the paper by Camilleri and Boeckxstaens1 which summarises the role of mast cells and their mediators in the pathogenesis of functional gastrointestinal disorders, and describes the particular role of histamine action on H1 receptors in submucosal neurons in rectal biopsies, as well as the clinical response to H1 blockade observed in some patients with the IBS. Mast cells are implicated in both IBS and to a lesser extent in functional dyspepsia.2 These cells release, among other mediators, histamine, which acts on histamine receptors on submucosal neurons, as well as on epithelial cells causing secretion of chloride and bicarbonate.2 Histamine-2 receptor blockade …