姜黄素
生物利用度
姜黄
化学
抗氧化剂
抗菌剂
螯合作用
水溶液中的金属离子
溶解度
生物活性
金属
药理学
生物化学
组合化学
体外
有机化学
传统医学
生物
医学
作者
Abolfazl Shakeri,Yunes Panahi,Thomas P. Johnston,Amirhossein Sahebkar
出处
期刊:Biofactors
[Wiley]
日期:2019-04-24
卷期号:45 (3): 304-317
被引量:73
摘要
Abstract Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa , has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low‐intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo‐complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin‐metal complexes. © 2019 BioFactors, 45(3):304–317, 2019
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