微生物群
细菌
生物
非核糖体肽
天然产物
基因
生物多样性
基因组
环境DNA
生物合成
计算生物学
生物技术
生态学
遗传学
生物化学
作者
Zachary Charlop–Powers,Clara C. Pregitzer,Christophe Lemetre,Melinda A. Ternei,Jeffrey Maniko,Bradley M. Hover,Paula Y. Calle,Krista L. McGuire,Jeanne Garbarino,Helen M. Forgione,Sarah Charlop‐Powers,Sean F. Brady
标识
DOI:10.1073/pnas.1615581113
摘要
Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These discovery efforts have principally focused on culturing bacteria from natural environments rich in biodiversity. We sought to assess the biosynthetic capacity of urban soil environments using a phylogenetic analysis of conserved NP biosynthetic genes amplified directly from DNA isolated from New York City park soils. By sequencing genes involved in the biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes are both rich in biosynthetic diversity and distinct from nonurban samples in their biosynthetic gene composition. A comparison of sequences derived from New York City parks to genes involved in the biosynthesis of biomedically important NPs produced by bacteria originally collected from natural environments around the world suggests that bacteria producing these same families of clinically important antibiotics, antifungals, and anticancer agents are actually present in the soils of New York City. The identification of new bacterial NPs often centers on the systematic exploration of bacteria present in natural environments. Here, we find that the soil microbiomes found in large cities likely hold similar promise as rich unexplored sources of clinically relevant NPs.
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