丁酸盐
短链脂肪酸
丙酸盐
益生元
背景(考古学)
炎症
癌变
动物研究
炎症性肠病
医学
药理学
疾病
生物
生物化学
内科学
发酵
癌症
古生物学
作者
Christina M. van der Beek,Cornelis H. C. Dejong,Freddy J. Troost,Ad Masclee,Kaatje Lenaerts
出处
期刊:Nutrition Reviews
[Oxford University Press]
日期:2017-04-01
卷期号:75 (4): 286-305
被引量:244
标识
DOI:10.1093/nutrit/nuw067
摘要
Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by microbial fermentation of undigested food substances are believed to play a beneficial role in human gut health. Short-chain fatty acids influence colonic health through various mechanisms. In vitro and ex vivo studies show that SCFAs have anti-inflammatory and anticarcinogenic effects, play an important role in maintaining metabolic homeostasis in colonocytes, and protect colonocytes from external harm. Animal studies have found substantial positive effects of SCFAs or dietary fiber on colonic disease, but convincing evidence in humans is lacking. Most human intervention trials have been conducted in the context of inflammatory bowel disease. Only a limited number of those trials are of high quality, showing little or no favorable effect of SCFA treatment over placebo. Opportunities for future research include exploring the use of combination therapies with anti-inflammatory drugs, prebiotics, or probiotics; the use of prodrugs in the setting of carcinogenesis; or the direct application of SCFAs to improve mucosal healing after colonic surgery.
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