材料科学
最小曲面
组织工程
立体光刻
脚手架
生物医学工程
表面改性
曲率
多孔性
生物相容性材料
曲面(拓扑)
3D打印
复合材料
纳米技术
化学工程
数学
工程类
几何学
作者
Sébastien Blanquer,Maike Werner,Markus Hannula,Shahriar Sharifi,Guillaume Lajoinie,David Eglin,Jari Hyttinen,Andreas A. Poot,Dirk W. Grijpma
出处
期刊:Biofabrication
[IOP Publishing]
日期:2017-04-12
卷期号:9 (2): 025001-025001
被引量:111
标识
DOI:10.1088/1758-5090/aa6553
摘要
Reproduction of the anatomical structures and functions of tissues using cells and designed 3D scaffolds is an ongoing challenge. For this, scaffolds with appropriate biomorphic surfaces promoting cell attachment, proliferation and differentiation are needed. In this study, eight triply-periodic minimal surface (TPMS)-based scaffolds were designed using specific trigonometric equations, providing the same porosity and the same number of unit cells, while presenting different surface curvatures. The scaffolds were fabricated by stereolithography using a photocurable resin based on the biocompatible, biodegradable and rubber-like material, poly(trimethylene carbonate) (PTMC). A numerical approach was developed to calculate the surface curvature distributions of the TPMS architectures. Moreover, the scaffolds were characterized by scanning electron microscopy, micro-computed tomography and water permeability measurements. These original scaffold architectures will be helpful to decipher the biofunctional role of the surface curvature of scaffolds intended for tissue engineering applications.
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