对映选择合成
布朗斯特德-洛瑞酸碱理论
化学
催化作用
阿托品
胺化
还原胺化
亲核加成
有机化学
亲核细胞
作者
Magnus Rueping,Boris J. Nachtsheim,Stefan A. Moreth,Michael Bolte
标识
DOI:10.1002/anie.200703668
摘要
Executive decision: Depending on the catalyst (both N-triflylphosphoramides), the highly enantioselective Brønsted acid catalyzed addition of indoles to α,β-unsaturated carbonyl compounds provides either α-keto esters (up to 92 % ee, left side of the scheme), or a novel type of bisindole (right), which displays atropisomerism. The α-keto esters can also be converted into amino acids by a one-pot 1,4-addition-reductive amination reaction.
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