纤溶酶
纤溶酶原激活剂
纤溶
蛋白酵素
化学
丝氨酸蛋白酶
尿激酶
蛋白酶
生物化学
纤维蛋白
舍宾
激肽释放酶
酶
生物
免疫学
内分泌学
内科学
医学
基因
遗传学
作者
Johann Schaller,Simon Gerber
标识
DOI:10.1007/s00018-010-0566-5
摘要
The plasmin–antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and α2-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(ogen) and α2-antiplasmin the system contains a series of specific activators and inhibitors. The main physiological activators of plasminogen are tissue-type plasminogen activator, which is mainly involved in the dissolution of the fibrin polymers by plasmin, and urokinase-type plasminogen activator, which is primarily responsible for the generation of plasmin activity in the intercellular space. Both activators are multidomain serine proteases. Besides the main physiological inhibitor α2-antiplasmin, the plasmin–antiplasmin system is also regulated by the general protease inhibitor α2-macroglobulin, a member of the protease inhibitor I39 family. The activity of the plasminogen activators is primarily regulated by the plasminogen activator inhibitors 1 and 2, members of the serine protease inhibitor superfamily.
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