全氟辛烷
绳索
男科
化学
胎儿
脐带血
血清浓度
磺酸盐
怀孕
免疫学
内科学
生物
医学
有机化学
遗传学
外科
钠
作者
Lin Yang,Zhen Wang,Yu Shi,Jingguang Li,Yuxin Wang,Yunfeng Zhao,Yongning Wu,Zongwei Cai
出处
期刊:Chemosphere
[Elsevier]
日期:2016-02-01
卷期号:144: 1631-1638
被引量:46
标识
DOI:10.1016/j.chemosphere.2015.10.063
摘要
Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.
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