化学
催化作用
光化学
亲核细胞
卤化物
激进的
复分解
芳基
烷基
催化循环
化学计量学
还原消去
药物化学
有机化学
聚合
聚合物
作者
Johannes Klett,Lukasz Wozniak,Nicolai Cramer
标识
DOI:10.1002/anie.202202306
摘要
1,3,2-diazaphospholenes hydrides (DAP-Hs) are highly nucleophilic organic hydrides serving as main-group catalysts for a range of attractive transformations. DAP hydrides can act as stoichiometric hydrogen atom transfer agents in radical reactions. Herein, we report a DAP-catalyzed reductive radical cyclization of a broad range of aryl and alkyl halides under mild conditions. The pivotal DAP catalyst turnover was achieved by a DBU-assisted σ-bond metathesis between the formed DAP halide and HBpin, which rapidly regenerates DAP-H. The transformation is significantly accelerated by irradiation with visible light. Mechanistic investigations indicate that visible light irradiation leads to the formation of DAP dimers, which are in equilibrium with DAP radicals and accelerate the cyclization. The direct use of (DAP)2 enabled a catalytic protocol in the absence of light.
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