伤口愈合
可穿戴计算机
胶粘剂
材料科学
医学
计算机科学
纳米技术
外科
嵌入式系统
图层(电子)
作者
So Yun Lee,Sangheon Jeon,Yong-Hwan Kwon,Mina Kwon,Moon Sung Kang,Keum‐Yong Seong,Tae-Eon Park,Seung Yun Yang,Dong‐Wook Han,Suck Won Hong,Ki Su Kim
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-04-15
卷期号:8 (15)
被引量:19
标识
DOI:10.1126/sciadv.abn1646
摘要
Wound healing is the dynamic tissue regeneration process replacing devitalized and missing tissue layers. With the development of photomedicine techniques in wound healing, safe and noninvasive photobiomodulation therapy is receiving attention. Effective wound management in photobiomodulation is challenged, however, by limited control of the geometrical mismatches on the injured skin surface. Here, adhesive hyaluronic acid-based gelatin nanofibrous membranes integrated with multiple light-emitting diode (LED) arrays are developed as a skin-attachable patch. The nanofibrous wound dressing is expected to mimic the three-dimensional structure of the extracellular matrix, and its adhesiveness allows tight coupling between the wound sites and the flexible LED patch. Experimental results demonstrate that our medical device accelerates the initial wound healing process by the synergetic effects of the wound dressing and LED irradiation. Our proposed technology promises progress for wound healing management and other biomedical applications.
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