Pd‐tBuONO Cocatalyzed Aerobic Indole Synthesis

Abstract A Pd‐ t BuONO co‐catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2‐vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti ‐breast cancer drug candidate 1 . magnified image