脑膜
脉络丛
神经科学
病理
脑脊液
骨髓
生物
神经炎症
细胞生物学
软脑膜
人口
室管膜细胞
薄壁组织
硬脑膜
祖细胞
中枢神经系统
解剖
干细胞
免疫学
医学
炎症
环境卫生
作者
David Schafflick,Jolien Wolbert,M. Heming,Christian Thomas,Maike Hartlehnert,Anna-Lena Börsch,Alessio Ricci,Sandra Martín-Salamanca,Xin Li,I-Na Lu,Mathias Pawlak,Jens Minnerup,Jan‐Kolja Strecker,Thomas Seidenbecher,Sven G. Meuth,Andrés Hidalgo,Arthur Liesz,Heinz Wiendl,Gerd Meyer zu Hörste
标识
DOI:10.1038/s41593-021-00880-y
摘要
The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings suggest that these CNS-associated border tissues have complex immunological functions. Unlike myeloid lineage cells, lymphocytes in border compartments have yet to be thoroughly characterized. Based on single-cell transcriptomics, we here identified a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS parenchyma, pia-enriched subdural meninges, dura mater, choroid plexus and cerebrospinal fluid. The dura layer of the meninges contained a large population of B cells under homeostatic conditions in mice and rats. Murine dura B cells exhibited slow turnover and long-term tissue residency, and they matured in experimental neuroinflammation. The dura also contained B lineage progenitors at the pro-B cell stage typically not found outside of bone marrow, without direct influx from the periphery or the skull bone marrow. This identified the dura as an unexpected site of B cell residence and potentially of development in both homeostasis and neuroinflammation.
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