원보 : 여주 활성 물질 Protocatechuic Acid의 신경세포의 산화적 스트레스에 대한 개선 효과

Protocatechuic acid is an active phenolic acid compound from Momordica charantia. In this study, we investigatedthe protective effect of protocatechuic acid against oxidative stress under cellular system using C6 glial cell. The oxidative stresswas induced by hydrogen peroxide (H2O2) and amyloid beta 25-35 (Aβ25-35), and they caused the decrease of cell viability andoverproduction of reactive oxygen species (ROS). However, the treatment of protocatechuic acid significantly elevated thedecreased cell viability and inhibited the overproduction of ROS by H2O2. In addition, protocatechuic acid significantly recoveredthe cellular damage induced by Aβ25-35. In particular, protocatechuic acid at the concentration 10 μg/mL decreased the elevatedROS level to normal level. These results indicate that protocatechuic acid may have neuroprotective effect throughattenuating oxidative stress.