壳聚糖
自愈水凝胶
伤口愈合
聚乙二醇
共聚物
伤口敷料
生物降解
没食子酸
乙二醇
化学
聚合物
材料科学
抗氧化剂
高分子化学
有机化学
外科
复合材料
医学
作者
Qida Zong,Xinxuan Peng,Detian Yan,Huiying Wu,Chenyang Lu,Jing Ye,Wei Sun,Jinwei Zhang,Yinglei Zhai
标识
DOI:10.1016/j.ijbiomac.2023.125138
摘要
The multifunctional hydrogel dressings are effective strategy to treat chronic wounds of diabetes. In addition, the ability of selective degradation on demand to change dressings could provide better patient compliance. Here, an injectable, self-healing hydrogel with rapid degradability on-demand is designed to promote the healing of diabetes wounds. The block copolymer formed by aldehyde modified aliphatic cyclic carbonate monomer with polyethylene glycol (MBP) and chitosan (CS) were crosslinked through the Schiff base bond to obtain a hydrogel with excellent injectability and self-healing ability. Due to the presence of carbonate bonds in MBP, it showed the rapid on-demand degradation characteristics triggered by N-acetylcysteine (NAC). At the same time, gallic acid (GA) was loaded into the hydrogel, giving the hydrogel dressing antioxidant. In vivo and in vitro experiments showed that the hydrogel wound dressing possesses good natures, such as antibacterial, antioxidant, and friendly cell compatibility, which could promote wound healing. Overall, the multifunctional hydrogel wound dressings with rapid on-demand degradation characteristics are more practical for clinical applications.
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