Oxidative C–H/N–H Carbonylation of Benzamide by Nickel Catalysis with CO as the Carbonyl Source

An efficient and direct carbonylation of aminoquinoline benzamides has been developed using abundant and inexpensive Ni(OAc)₂·4H₂O as the catalyst and carbon monoxide as a cost-efficient C1 building block. This process features good functional-group tolerance and can be conducted on gram scale. The directing group can be easily removed under mild conditions.