0232 Association of Sleep Quality and Sleep Duration with Cognitive Frailty in Older Chinese Adults

Abstract Introduction Cognitive frailty refers to the co-occurrence of physical frailty and cognitive impairment. The aim of this study is to examine the associations of sleep quality and sleep duration with cognitive frailty among older Chinese adults. Methods We analyzed data from the 2008 wave of the Chinese Longitudinal Healthy Longevity Survey. In total, 11,293 participants aged ≥ 65 years old (mean age 85 years; 6032 females) who had cognition and physical frailty assessments at baseline were included. Participants were considered physically frail when meeting ≥3 of the following criteria: shrinking, weakness, slowness, exhaustion, and inactivity; and were considered mild cognitive impairment if the Mini-Mental State Examination score ◻22. Cognitive frailty was identified as the presence of both physical frailty and mild cognitive impairment. Sleep quality was assessed based on answers to the question “How about the quality of your sleep?” A score “poor” was rendered if the answer was “so so”, “bad”, or “very bad”, and a score “good” was rendered otherwise. Sleep duration was estimated based on the answers to the question “How many hours do you sleep normally?”, was further categorized into short (< 6 h), normal (6-9 h), and long (>9 h). Multivariate logistic regression models were performed to assess the associations of sleep quality and sleep duration with cognitive frailty adjusting for age, sex, education, residence, economic status, marital status, and multimorbidity. Results Among all participants, 1,297 (11.5%) were identified as having cognitive frailty. Poor sleep quality was found in 3,794 (33.6 %) participants. Numbers of participants who reported short, normal, or long sleep duration were 1,325 (11.7%), 7,200 (63.8%), and 2,768 (24.5%). Compared with those who had good quality, participants who had poor sleep quality were at a higher risk for cognitive frailty (odds ratio [OR]=1.36, 95%CI=1.19-1.56, p< 0.001). Compared to participants who had normal sleep duration, the odds of having cognitive frailty were also higher in those with short (OR=1.29, 95%CI=1.05-1.59, p< 0.05) or long sleep duration (OR=1.52, 95%CI=1.32-1.74, p< 0.001). Conclusion Poor sleep quality and abnormal sleep duration were associated with cognitive frailty among older Chinese adults. Support (if any) BrightFocus Foundation (A2020886S), NIH RF1AG064312