蛋氨酸腺苷转移酶
细胞凋亡
甲基转移酶
化学
酶
生物化学
蛋氨酸
癌细胞
癌症研究
生物
癌症
甲基化
遗传学
基因
氨基酸
作者
Yi-Fei Xuan,Shan Lü,Yen‐Chuan Ou,Xu-Bin Bao,Xia‐Juan Huan,Shanshan Song,Ze‐Hong Miao,Ying-Qing Wang
标识
DOI:10.1016/j.bbrc.2024.150011
摘要
Methionine adenosyltransferase 2 A (MAT2A) mediates the synthesis of methyl donor S-Adenosylmethionine (SAM), providing raw materials for methylation reactions in cells. MAT2A inhibitors are currently used for the treatment of tumors with methylthioadenosine phosphorylase (MTAP) deficiency in clinical research. Methyltransferase like 3 (METTL3) catalyzes N6-methyladenosine (m
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