纳米载体
过氧化氢
化学
药物输送
药品
癌症治疗
肿瘤微环境
癌症治疗
药理学
纳米技术
癌症
生物化学
癌症研究
医学
材料科学
有机化学
肿瘤细胞
内科学
作者
Lu Li,Yue Tian,Jie Feng,Yujun Zhang,Jianquan Hou,Yi Wang
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2024-01-01
摘要
Lactate oxidase (LOX) is a natural enzyme that efficiently consumes lactate. In the presence of oxygen, LOX can catalyse the formation of pyruvate and hydrogen peroxide (H2O2) from lactate. This process led to acidity alleviation, hypoxia, and a further increase in oxidative stress, alleviating the immunosuppressive state of the tumour microenvironment (TME). However, the high cost of LOX preparation and purification, poor stability, and systemic toxicity limited its application in tumour therapy. Therefore, the rational application of drug delivery systems can protect LOX from the organism's environment and maintain its catalytic activity. This paper reviews various LOX-based drug-carrying systems, including inorganic nanocarriers, organic nanocarriers, and inorganic-organic hybrid nanocarriers, as well as other non-nanocarriers, which have been used for tumour therapy in recent years. In addition, this area's challenges and potential for the future are highlighted.
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