Commentary: Safety and efficacy of low-cost alternative urokinase in acute ischemic stroke: A systematic review and meta-analysis

• We would like to share our ideas on the recent publication by Kharel et al. in evaluation the safety and efficacy of low-cost alternative urokinase in acute ischemic stroke through a systematic review and meta-analysis by pooling the open published data in Journal of Clinical Neuroscience (Official Journal of the Neurosurgical Society of Australasia). • The authors made the conclusion that intravenous UK was not inferior to alteplase in terms of safety and efficacy and could be a viable alternative for intravenous thrombolysis (IVT) in ischemic stroke (AIS) patients in low-and middle-income countries (LMICs). • Generally, the work is interesting and well prepared with great clinical significance . • However, in order to further improve the quality and readability of the paper, we believe that some issues need to be discussed.