恩帕吉菲
内分泌学
运输机
胰岛素抵抗
糖尿病肾病
新陈代谢
内科学
2型糖尿病
糖尿病
化学
表观遗传学
碳水化合物代谢
生物
医学
生物化学
基因
作者
Blythe D. Shepard,Jennifer Chau,Ryan Kurtz,Avi Z. Rosenberg,Pinaki Sarder,Scott Border,Brandon Ginley,Olga Rodriguez,Chris Albanese,Grace Knoer,Aarenee Greene,Aline Maria Arlindo de Souza,Suman Ranjit,Moshe Levi,Carolyn M. Ecelbarger
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2024-04-01
卷期号:326 (4): C1272-C1290
标识
DOI:10.1152/ajpcell.00446.2023
摘要
Renal protection afforded by sodium glucose transporter, type 2 inhibitors (SGLT2i), e.g., empagliflozin (EMPA) involves complex intertwined mechanisms. Using a novel mouse model of obesity with insulin resistance, the TallyHo/Jng (TH) mouse on a high-milk-fat diet (HMFD), we found subtle changes in metabolism including altered regulation of sodium transporters that line the renal tubule. New potential epigenetic determinants of metabolic changes relating to FOXO and cancer signaling pathways were elucidated from an altered urine exosomal microRNA signature.
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