双糖
糖苷
化学
细胞毒性T细胞
立体化学
脂多糖
体外
传统医学
生物化学
生物
医学
免疫学
作者
Yunpeng Qin,Wanqi Yang,Kai-Dong Liu,Yong Xu,Yingying Dong,Jiang Fu,Jing Qu,Shi‐Shan Yu
标识
DOI:10.1080/10286020.2023.2293080
摘要
A new disaccharide glycoside, franchoside A (1), and 17 known compounds were isolated from the tubers of Arisaema franchetianum Engler. The chemical structure of the previously undescribed compound 1 was elucidated on the basis of detailed spectroscopic analyses. Compounds 1, 2, 6, 10, 14 and 18 showed significant cytotoxic activities at varying IC50 values in the range of 4.0-10.6 μM against five cancer cell lines. Compounds 8, 10, 13 and 17 (10 μM) exhibited moderate anti-inflammatory activities by inhibiting the NF-κB signaling pathway and the release of NO from RAW264.7 macrophages induced by lipopolysaccharide (LPS), while compounds 1, 9, 14, 15 and 16 showed weak anti-inflammatory activities.
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