Perfluorobutane-enhanced US Helps Differentiate Benign Lymph Nodes from Papillary Thyroid Cancer Metastases

HomeRadiologyRecently Published PreviousNext Reviews and CommentaryEditorialPerfluorobutane-enhanced US Helps Differentiate Benign Lymph Nodes from Papillary Thyroid Cancer MetastasesGowthaman Gunabushanam Gowthaman Gunabushanam Author AffiliationsFrom the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520-8042.Address correspondence to the author (email: [email protected]).Gowthaman Gunabushanam Published Online:Apr 4 2023https://doi.org/10.1148/radiol.230581MoreSectionsFull textPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In References1. Leenhardt L, Erdogan MF, Hegedus L, et al. 2013 European thyroid association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J 2013;2(3):147–159. Crossref, Medline, Google Scholar2. Zhao H, Li H. Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: Diagnosis of central and lateral compartment nodal metastases. Eur J Radiol 2019;112:14–21. Crossref, Medline, Google Scholar3. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid 2016;26(1):1–133. Crossref, Medline, Google Scholar4. Xiao L, Zhou J, Tan W, et al. Contrast-enhanced US with Perfluorobutane to diagnose small lateral cervical lymph node metastases of papillary thyroid carcinoma. Radiology 2023. https://doi.org/10.1148/radiol.221465. Published online April 4, 2023. Medline, Google Scholar5. Frinking P, Segers T, Luan Y, Tranquart F. Three decades of ultrasound contrast agents: A review of the past, present and future improvements. Ultrasound Med Biol 2020;46(4):892–908. Crossref, Medline, Google Scholar6. Yu Y, Shi LL, Zhang HW, Wang Q. Performance of contrast-enhanced ultrasound for lymph node metastasis in papillary thyroid carcinoma: a meta-analysis. Endocr Connect 2023;12(2):e220341. Crossref, Medline, Google Scholar7. Chen L, Chen L, Liu J, Wang B, Zhang H. Value of qualitative and quantitative contrast-enhanced ultrasound analysis in preoperative diagnosis of cervical lymph node metastasis from papillary thyroid carcinoma. J Ultrasound Med 2020;39(1):73–81. Crossref, Medline, Google Scholar8. Hong YR, Luo ZY, Mo GQ, Wang P, Ye Q, Huang PT. Role of contrast-enhanced ultrasound in the pre-operative diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma. Ultrasound Med Biol 2017;43(11):2567–2575. Crossref, Medline, Google Scholar9. Wei Y, Yu MA, Niu Y, et al. Combination of lymphatic and intravenous contrast-enhanced ultrasound for evaluation of cervical lymph node metastasis from papillary thyroid carcinoma: a preliminary study. Ultrasound Med Biol 2021;47(2):252–260. Crossref, Medline, Google Scholar10. Wei Y, Niu Y, Zhao ZL, et al. Effectiveness of Lymphatic Contrast Enhanced Ultrasound in the diagnosis of Cervical Lymph node metastasis from papillary thyroid carcinoma. Sci Rep 2022;12(1):578. Crossref, Medline, Google ScholarArticle HistoryReceived: Mar 6 2023Revision requested: Mar 8 2023Revision received: Mar 8 2023Accepted: Mar 13 2023Published online: Apr 04 2023 FiguresReferencesRelatedDetailsAccompanying This ArticleContrast-enhanced US with Perfluorobutane to Diagnose Small Lateral Cervical Lymph Node Metastases of Papillary Thyroid CarcinomaApr 4 2023RadiologyRecommended Articles RSNA Education Exhibits RSNA Case Collection Recently Published Metrics Altmetric Score PDF download