过氧化氢
催化作用
电化学
氧化应激
脐静脉
氧气
化学
活性氧
干扰(通信)
碳纳米管
材料科学
生物物理学
纳米技术
电极
物理化学
计算机科学
体外
生物
有机化学
生物化学
计算机网络
频道(广播)
作者
Meihong Peng,Jing Jiang,Shutong Chen,Kai Li,Yuqing Lin
出处
期刊:Analyst
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:148 (22): 5667-5672
被引量:1
摘要
The study of cellular responses linked to oxidative stress mechanisms is crucial in comprehending diverse physiological and pathological life processes, including mitochondrial dysfunction. Nonetheless, despite the interference of O2, the monitoring of ROS released from cells poses a challenging task. In this study, carbon-based copper single-atom catalysts (Cu SACs) were synthesized that exhibits excellent electrocatalytic performance for H2O2 reduction with an initial potential at 0.23 V and effectively avoids interference from O2. Based on this catalyst, a flexible and stretchable oxygen-tolerant sensor was constructed and applied to monitor the calcium ion-induced ROS burst in human umbilical vein endothelial cells (HUVECs) in a simulated physiological condition. This study effectively eradicates interference that may arise from the reduction of O2 and presents a dependable platform for real-time in situ monitoring of physiologically active molecules by utilizing H2O2 detection.
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