Metal- and Hazardous Reagent-Free Transamidation Process: the NH2OH⦁HCl Promoted N-Formylation and N-Acylation Reaction under Solvent-Less Conditions

AbstractAn efficient transamidation process has been described under solvent-less conditions. The transformation has been accomplished by employing NH2OH⦁HCl as a reagent and amines as substrates. The developed method is achieved in the absence of metals and hazardous reagents. A series of amines were explored to obtain the N-formylation and N-acylation reactions with excellent yields (81-96%) of products. The DFT analysis was also performed, which provides a clear understanding of the described N-formylation process. The postulated mechanism is well supported by the control experiments.Keywords: TransamidationC-N bond formationamidesNH2OH⦁HCl reagentDFT analysis AcknowledgementsCCM appreciates the Science and Engineering Research Board (SERB), New Delhi for financial supports in the form of research grants (CRG/2020/004509 and ECR/2016/000337). KK and DK are grateful to the Ministry of Education (MoE), New Delhi for fellowship supports. The authors extend their appreciation to the Researchers Supporting Project number (RSP2023R396), King Saud University, Riyadh, Saudi Arabia.Disclosure statementNo potential conflict of interest was reported by the author(s).Author contributionsThe manuscript was written through contributions of all authors and all authors have given approval to the final version of the manuscript.