Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2 ‐related disorders

This study identifies that the age-related spontaneous remission of seizures is due to time-limited changes in neuronal excitability, and treatment interventions for KCNQ2-DEE patients need to consider critical developmental time windows. In the future, better therapeutic outcomes may be achieved through spatiotemporal transcriptional coordination with neurodevelopmental gene networks.