Harnessing the apical sodium-dependent bile acid transporter for enhanced oral delivery of peptide drugs: mechanisms, strategies, and therapeutic potential

Current strategies predominantly rely on passive transport or paracellular transport, which, despite being widely used, suffer from low transport efficiency. On the other hand, active transport via other intestinal transporters is often limited by transporter abundance and capacity. In contrast, ASBT-mediated transport offers a high-capacity, efficient, and safe mechanism with sufficient transporter expression in the intestine, making it a promising alternative for oral PDs delivery.